Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials.

Felipe M Delpino; Lílian M Figueiredo; Scott C Forbes; Darren G Candow; Heitor O Santos

Nutrition (Burbank, Los Angeles County, Calif.), 2022

Metadata only. The abstract is not shown here; read it at the publisher or on PubMed.

Abstract

The abstract is not shown here because of the article's licence. Read it on PubMed.

Read the abstract on PubMed

Where this study is used

Creatine monohydrate supplementation: Lean / fat-free mass (Adults) — Moderate. Counted in the grade.
Creatine monohydrate supplementation: Lean / fat-free mass (Adults) — High. Counted in the grade.
Creatine monohydrate supplementation: Lean / fat-free mass (Adults) — Moderate. Counted in the grade.

Extracted values

AI-assisted extraction: each number comes with the sentence it was read from.

Studies pooled: 35
Participants pooled: 1192

Study-level values with their source sentences
Field	Value	Source sentence
Review question	Therefore, the aim of this study was to systematically review and meta-analyze randomized controlled trials (RCTs) investigating creatine supplementation on LBM.	Show quote for Review question Therefore, the aim of this study was to systematically review and meta-analyze randomized controlled trials (RCTs) investigating creatine supplementation on LBM. Located at `abs:0/s:1`
Intervention · Agent	creatine supplementation	Show quote for Intervention · Agent investigating creatine supplementation on LBM Located at `abs:0/s:1`
N studies	35	Show quote for N studies Thirty-five studies were included Located at `abs:0/s:6`
N participants	1192	Show quote

How these values were extracted

Model claude-haiku-5-5+claude-sonnet-5-5, run on 26 Oct 2026. 2 passes, 58% agreement between passes. 0 fields checked by a person.

Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials.

Felipe M Delpino; Lílian M Figueiredo; Scott C Forbes; Darren G Candow; Heitor O Santos

Nutrition (Burbank, Los Angeles County, Calif.), 2022

Metadata only. The abstract is not shown here; read it at the publisher or on PubMed.

Extracted values

AI-assisted extraction: each number comes with the sentence it was read from.

Studies pooled: 35
Participants pooled: 1192

Study-level values with their source sentences
Field	Value	Source sentence
Review question	Therefore, the aim of this study was to systematically review and meta-analyze randomized controlled trials (RCTs) investigating creatine supplementation on LBM.	Show quote for Review question Therefore, the aim of this study was to systematically review and meta-analyze randomized controlled trials (RCTs) investigating creatine supplementation on LBM. Located at `abs:0/s:1`
Intervention · Agent	creatine supplementation	Show quote for Intervention · Agent investigating creatine supplementation on LBM Located at `abs:0/s:1`
N studies	35	Show quote for N studies Thirty-five studies were included Located at `abs:0/s:6`
N participants	1192	Show quote

How these values were extracted

Model claude-haiku-5-5+claude-sonnet-5-5, run on 26 Oct 2026. 2 passes, 58% agreement between passes. 0 fields checked by a person.

Field	Value	Source sentence
Outcome name	LBM	Show quote for Outcome name creatine increased LBM by 0.68 kg (95% confidence interval [CI], 0.26-1.11) Located at `abs:0/s:7`
Point estimate	0.68	Show quote for Point estimate creatine increased LBM by 0.68 kg (95% confidence interval [CI], 0.26-1.11) Located at `abs:0/s:7`
Ci low	0.26	Show quote for Ci low creatine increased LBM by 0.68 kg (95% confidence interval [CI], 0.26-1.11) Located at `abs:0/s:7`
Ci high	1.11	Show quote for Ci high creatine increased LBM by 0.68 kg (95% confidence interval [CI], 0.26-1.11) Located at `abs:0/s:7`
Ci level	95	Show quote for Ci level creatine increased LBM by 0.68 kg (95% confidence interval [CI], 0.26-1.11) Located at `abs:0/s:7`
Unit	kg	Show quote for Unit creatine increased LBM by 0.68 kg Located at `abs:0/s:7`
Analysis kind	primary	Show quote for Analysis kind Overall (i.e., inclusion of all studies with and without exercise training interventions) revealed that creatine increased LBM by 0.68 kg (95% confidence interval [CI], 0.26-1.11). Located at `abs:0/s:7`

Field	Value	Source sentence
Outcome name	LBM	Show quote for Outcome name Subanalyses revealed greater gains in LBM when creatine was combined with resistance training (mean difference [MD], 1.10 kg; 95% CI, 0.56-1.65) Located at `abs:0/s:8`
Effect measure	MD	Show quote for Effect measure mean difference [MD], 1.10 kg Located at `abs:0/s:8`
Effect measure as written	mean difference [MD]	Show quote for Effect measure as written mean difference [MD], 1.10 kg Located at `abs:0/s:8`
Point estimate	1.1	Show quote for Point estimate mean difference [MD], 1.10 kg; 95% CI, 0.56-1.65 Located at `abs:0/s:8`
Ci low	0.56	Show quote for Ci low mean difference [MD], 1.10 kg; 95% CI, 0.56-1.65 Located at `abs:0/s:8`
Ci high	1.65	Show quote for Ci high mean difference [MD], 1.10 kg; 95% CI, 0.56-1.65 Located at `abs:0/s:8`
Ci level	95	Show quote for Ci level 95% CI, 0.56-1.65 Located at `abs:0/s:8`
Unit	kg	Show quote for Unit 1.10 kg Located at `abs:0/s:8`
Subgroup	when creatine was combined with resistance training	Show quote for Subgroup when creatine was combined with resistance training Located at `abs:0/s:8`
Analysis kind	subgroup	Show quote for Analysis kind Subanalyses revealed greater gains in LBM when creatine was combined with resistance training Located at `abs:0/s:8`

Field	Value	Source sentence
Outcome name	LBM	Show quote for Outcome name There was no statistically significant effect of creatine on LBM when combined with mixed exercise (MD, 0.74 kg; 95% CI, -3.89 to 5.36) Located at `abs:0/s:9`
Effect measure	MD	Show quote for Effect measure MD, 0.74 kg Located at `abs:0/s:9`
Effect measure as written	MD	Show quote for Effect measure as written MD, 0.74 kg Located at `abs:0/s:9`
Point estimate	0.74	Show quote for Point estimate MD, 0.74 kg; 95% CI, -3.89 to 5.36 Located at `abs:0/s:9`
Ci low	−3.89	Show quote for Ci low MD, 0.74 kg; 95% CI, -3.89 to 5.36 Located at `abs:0/s:9`
Ci high	5.36	Show quote for Ci high MD, 0.74 kg; 95% CI, -3.89 to 5.36 Located at `abs:0/s:9`
Ci level	95	Show quote for Ci level 95% CI, -3.89 to 5.36 Located at `abs:0/s:9`
Unit	kg	Show quote for Unit MD, 0.74 kg Located at `abs:0/s:9`
Subgroup	when combined with mixed exercise	Show quote for Subgroup when combined with mixed exercise Located at `abs:0/s:9`
Analysis kind	subgroup	Show quote for Analysis kind There was no statistically significant effect of creatine on LBM when combined with mixed exercise Located at `abs:0/s:9`

Field	Value	Source sentence
Outcome name	LBM	Show quote for Outcome name There was no statistically significant effect of creatine on LBM when combined with mixed exercise (MD, 0.74 kg; 95% CI, -3.89 to 5.36) or without exercise (MD, 0.03 kg; 95% CI, -0.65 to 0.70) Located at `abs:0/s:9`
Effect measure	MD	Show quote for Effect measure MD, 0.03 kg Located at `abs:0/s:9`
Effect measure as written	MD	Show quote for Effect measure as written MD, 0.03 kg Located at `abs:0/s:9`
Point estimate	0.03	Show quote for Point estimate MD, 0.03 kg; 95% CI, -0.65 to 0.70 Located at `abs:0/s:9`
Ci low	−0.65	Show quote for Ci low MD, 0.03 kg; 95% CI, -0.65 to 0.70 Located at `abs:0/s:9`
Ci high	0.7	Show quote for Ci high MD, 0.03 kg; 95% CI, -0.65 to 0.70 Located at `abs:0/s:9`
Ci level	95	Show quote for Ci level 95% CI, -0.65 to 0.70 Located at `abs:0/s:9`
Unit	kg	Show quote for Unit MD, 0.03 kg Located at `abs:0/s:9`
Subgroup	without exercise	Show quote for Subgroup or without exercise Located at `abs:0/s:9`
Analysis kind	subgroup	Show quote for Analysis kind There was no statistically significant effect of creatine on LBM when combined with mixed exercise (MD, 0.74 kg; 95% CI, -3.89 to 5.36) or without exercise Located at `abs:0/s:9`

Field	Value	Source sentence
Outcome name	LBM	Show quote for Outcome name Further subanalyses found that males on creatine increased LBM by 1.46 kg (95% CI, 0.47-2.46), compared with a non-significant increase of 0.29 kg (95% CI, -0.43 to 1.01) for females. Located at `abs:0/s:10`
Point estimate	1.46	Show quote for Point estimate males on creatine increased LBM by 1.46 kg (95% CI, 0.47-2.46) Located at `abs:0/s:10`
Ci low	0.47	Show quote for Ci low males on creatine increased LBM by 1.46 kg (95% CI, 0.47-2.46) Located at `abs:0/s:10`
Ci high	2.46	Show quote for Ci high males on creatine increased LBM by 1.46 kg (95% CI, 0.47-2.46) Located at `abs:0/s:10`
Ci level	95	Show quote for Ci level (95% CI, 0.47-2.46) Located at `abs:0/s:10`
Unit	kg	Show quote for Unit males on creatine increased LBM by 1.46 kg Located at `abs:0/s:10`
Subgroup	males	Show quote for Subgroup males on creatine increased LBM by 1.46 kg Located at `abs:0/s:10`
Analysis kind	subgroup	Show quote for Analysis kind Further subanalyses found that males on creatine increased LBM by 1.46 kg Located at `abs:0/s:10`

Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials.

Abstract

Where this study is used

Extracted values

How these values were extracted

Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials.

Abstract

Where this study is used

Extracted values

How these values were extracted

LBM

LBM · when creatine was combined with resistance training

LBM · when combined with mixed exercise

LBM · without exercise

LBM · males

LBM · females